Seth L Alper Selected Research

Chloride-Bicarbonate Antiporters

2/2017	Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis.
1/2011	Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
9/2007	Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.
5/2007	Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1).
1/2002	Genetic diseases of acid-base transporters.

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Seth L Alper Research Topics

Disease

12	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 01/2020 - 01/2002
10	Kidney Diseases (Kidney Disease) 01/2022 - 02/2015
8	Neoplasms (Cancer) 01/2021 - 01/2002
6	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 01/2016
6	Dehydration (Water Stress) 03/2020 - 06/2007
6	Autosomal Dominant Polycystic Kidney (ADPKD) 09/2011 - 02/2002
4	Brain Edema (Cerebral Edema) 10/2020 - 05/2007
4	Inflammation (Inflammations) 01/2020 - 01/2013
4	Goiter 12/2016 - 01/2011
4	Deafness (Deaf Mutism) 12/2016 - 01/2002
4	Acidosis 11/2016 - 05/2007
4	Diarrhea 01/2015 - 01/2002
3	Anaphylaxis (Anaphylactic Shock) 06/2022 - 11/2016
3	Fibrosis (Cirrhosis) 01/2021 - 01/2013
3	Peritoneal Fibrosis 01/2021 - 01/2012
3	Peritonitis 01/2018 - 01/2016
3	Ischemic Stroke 08/2017 - 07/2015
3	Hypertension (High Blood Pressure) 08/2017 - 11/2010
3	Cystic Fibrosis (Mucoviscidosis) 01/2017 - 08/2011
3	Pendred syndrome 12/2016 - 01/2011
3	Nephrolithiasis 01/2016 - 03/2008
3	Hemolytic Anemia 10/2015 - 05/2007
2	Hypoxia (Hypoxemia) 01/2022 - 01/2010
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 11/2020 - 06/2020
2	Acute Lung Injury 11/2020 - 06/2020
2	Hydrocephalus (Hydrocephaly) 01/2020 - 08/2017
2	hereditary Xerocytosis 01/2019 - 01/2017
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2019 - 02/2015
2	Renal Insufficiency (Renal Failure) 01/2018 - 05/2017
2	Hyperoxaluria (Oxaluria) 01/2017 - 01/2016
2	Anemia 01/2014 - 05/2011
2	Hearing Loss (Hearing Impairment) 05/2013 - 08/2009
2	Osteopetrosis 02/2013 - 01/2002
2	Heart Failure 01/2013 - 01/2011
2	Sensorineural Hearing Loss 01/2011 - 01/2011
2	Cysts 06/2009 - 03/2007
2	Insulin Resistance 12/2005 - 05/2004
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 09/2004 - 10/2003
1	Shock 06/2022
1	Hereditary Spherocytosis 10/2021
1	Rare Diseases (Rare Disease) 01/2021
1	Trigeminal Neuralgia (Tic Douloureux) 10/2020
1	Facial Pain (Myofacial Pain) 10/2020
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 06/2020
1	COVID-19 06/2020
1	Lung Diseases (Lung Disease) 06/2020
1	Lung Injury 06/2020
1	Gliosis 01/2020
1	Proteinuria 01/2020

Drug/Important Bio-Agent (IBA)

10	CationsIBA 01/2022 - 02/2002
9	dirhodium tetraacetate (DRTA)IBA 05/2017 - 01/2002
7	AcidsIBA 01/2022 - 01/2002
7	Apolipoprotein L1IBA 01/2022 - 02/2015
6	Mucin-1 (CA 15-3 Antigen)IBA 01/2021 - 03/2013
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2002
6	Phosphotransferases (Kinase)IBA 08/2017 - 10/2003
5	K Cl- CotransportersIBA 03/2020 - 03/2007
5	Chloride-Bicarbonate AntiportersIBA 02/2017 - 01/2002
5	Peptides (Polypeptides)IBA 12/2016 - 03/2007
5	AnionsIBA 01/2016 - 03/2008
5	ChloridesIBA 01/2015 - 01/2002
4	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 01/2002
4	Erythrocyte Anion Exchange Protein 1 (Band 3 Protein)IBA 02/2017 - 01/2002
4	OxalatesIBA 01/2017 - 03/2008
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 06/2009
2	Grammostola spatulata MTx4 proteinIBA 01/2022 - 01/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2014
2	NucleotidesIBA 01/2021 - 06/2009
2	fostamatinibIBA 11/2020 - 06/2020
2	Syk KinaseIBA 11/2020 - 06/2020
2	Biomarkers (Surrogate Marker)IBA 06/2020 - 01/2016
2	CytokinesIBA 01/2020 - 01/2016
2	OvalbuminIBA 01/2019 - 11/2016
2	Bumetanide (Bumex)FDA LinkGeneric 08/2017 - 07/2015
2	senicapocIBA 01/2017 - 01/2016
2	xylometazoline (stas)IBA 12/2016 - 04/2013
2	PotassiumIBA 01/2016 - 06/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 07/2015
2	Oxygen (Dioxygen)IBA 07/2015 - 01/2002
2	IodidesIBA 05/2013 - 01/2011
2	Messenger RNA (mRNA)IBA 01/2013 - 06/2009
2	TRPP Cation ChannelsIBA 09/2011 - 03/2007
2	Carbonic Anhydrase IIIBA 11/2010 - 01/2002
2	Insulin-Like Growth Factor I (IGF-1)IBA 03/2007 - 09/2004
2	Insulin-Like PeptidesIBA 03/2007 - 09/2004
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2022
1	Suramin (Suramin Sodium)IBA 01/2022
1	Apyrase (ATP Diphosphatase)IBA 01/2022
1	Probenecid (Benemid)FDA LinkGeneric 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Lithium ChlorideIBA 01/2021
1	Crystallins (Crystallin)IBA 01/2021
1	gamma-Aminobutyric Acid (GABA)IBA 10/2020
1	Pharmaceutical PreparationsIBA 06/2020
1	Ketamine FDA LinkGeneric 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	GlobinsIBA 01/2020
1	Protons (Proton)IBA 01/2020

Therapy/Procedure

10	Therapeutics 01/2021 - 01/2002
4	Peritoneal Dialysis 01/2017 - 01/2012